Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure

Mehra, Mandeep R., Lavie, Carl J., Ventura, Hector O. and Milani, Richard V. (2006). Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure. In: Journal of Heart and Lung Transplantation. 25th Annual Meeting of the International Society of Heart and Lung Transplantation, Philadelphia, PA, United States, (834-838). 6-9 April 2005. doi:10.1016/j.healun.2006.03.005


Author Mehra, Mandeep R.
Lavie, Carl J.
Ventura, Hector O.
Milani, Richard V.
Title of paper Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure
Conference name 25th Annual Meeting of the International Society of Heart and Lung Transplantation
Conference location Philadelphia, PA, United States
Conference dates 6-9 April 2005
Proceedings title Journal of Heart and Lung Transplantation   Check publisher's open access policy
Journal name Journal of Heart and Lung Transplantation   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Elsevier
Publication Year 2006
Sub-type Fully published paper
DOI 10.1016/j.healun.2006.03.005
ISSN 1053-2498
1557-3117
Volume 25
Issue 7
Start page 834
End page 838
Total pages 4
Language eng
Formatted Abstract/Summary
Background

Fish oils have been shown to reduce production of tumor necrosis factor-alpha (TNF-α) in healthy subjects. We sought to evaluate the effects of fish oils on pro-inflammatory cytokines and body weight in patients with advanced heart failure.

Methods

Fourteen patients (New York Heart Association [NYHA] Class III to IV heart failure) were randomized in a double-blinded trial to active therapy with 8 g of n-3 fatty acids (Group A, n = 7) or placebo (Group B, n = 7) for 18 weeks. TNF-α and interleukin-1 (IL-1) production were measured by radioimmunoassay after endotoxin stimulation of peripheral blood mononuclear cells.

Results

Placebo-treated patients had a 44% increase in TNF-α (from 1.28 to 1.84 pg/ml; p = 0.07) but no significant change in IL-1 (from 0.68 to 0.78 pg/ml) production. n-3 fatty acids resulted in a 59% reduction in TNF-α (from 1.64 to 0.68 pg/ml; p = 0.02) and 39% decrease in IL-1 (from 1.98 to 1.21 pg/ml; p = 0.09) production. There was an inverse correlation between change in TNF-α production and change in percent body fat (r = −0.6; p = 0.02).

Conclusions

Fish oils decrease TNF-α production in heart failure and improve body weight. Fish oil therapy may represent a novel therapeutic approach in late-stage heart failure characterized by cardiac cachexia.
Keyword Tumor-necrosis-factor
Targeted Anticytokine therapy
Polyunsaturated Fatty-acids
Blood Mononuclear-cells
Dietary Supplementation
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

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Created: Mon, 14 Mar 2011, 09:34:03 EST