Efficacy and Safety of intensive statin therapy in the elderly

Maroo, B. P., Lavie, C. J. and Milani, R. V. (2008) Efficacy and Safety of intensive statin therapy in the elderly. American journal of geriatric cardiology, 17 2: 92-100.

Author Maroo, B. P.
Lavie, C. J.
Milani, R. V.
Title Efficacy and Safety of intensive statin therapy in the elderly
Journal name American journal of geriatric cardiology   Check publisher's open access policy
ISSN 1076-7460
1751-715X
Publication date 2008-03
Sub-type Critical review of research, literature review, critical commentary
Volume 17
Issue 2
Start page 92
End page 100
Total pages 9
Place of publication Gardendale, AL, United States
Publisher Society of Geriatric Cardiology
Language eng
Abstract Numerous epidemiologic and intervention trials, including many studying elderly cohorts, have demonstrated the importance of lipids in primary and secondary preventions of cardiovascular diseases, including coronary heart disease (CHD) and stroke. More recent studies have demonstrated that more intensive statin therapy that reduces low-density lipoprotein cholesterol levels to <70 to 80 mg/dL have resulted in more marked cardiovascular event reduction than less intensive statin treatment. The authors review the efficacy and safety of intensive vs less intensive statin therapy. Specifically, 4 such studies with sufficient data in elderly patients, including 2 trials of patients with stable CHD and 2 with acute coronary syndrome, demonstrating the efficacy and safety of intensive statin therapy with high-dose (80 mg) atorvastatin are reviewed in detail. Although elderly patients may be more susceptible to drug interactions when receiving high doses of statins, the present evidence supports the use of intensive statin therapy in most high-risk elderly patients both with stable CHD and following acute coronary syndrome.
Keyword RANDOMIZED CONTROLLED-TRIAL
ACUTE CORONARY SYNDROMES
LIPID-LOWERING THERAPY
DENSITY-LIPOPROTEIN CHOLESTEROL
MYOCARDIAL-ISCHEMIA REDUCTION
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:33:49 EST