Renin-angiotensin system: Genes to bedside

Malik, Furrukh S., Lavie, CarlJ., Mehra, Mandeep R., Milani, Richard V. and Re, Richard N. (1997) Renin-angiotensin system: Genes to bedside. American Heart Journal, 134 3: 514-526. doi:10.1016/S0002-8703(97)70089-9

Author Malik, Furrukh S.
Lavie, CarlJ.
Mehra, Mandeep R.
Milani, Richard V.
Re, Richard N.
Title Renin-angiotensin system: Genes to bedside
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
Publication date 1997-09
Sub-type Article (original research)
DOI 10.1016/S0002-8703(97)70089-9
Volume 134
Issue 3
Start page 514
End page 526
Total pages 13
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Atherosclerosis and its vascular sequela are responsible for considerable morbidity and mortality rates. Several risk factors have been implicated in the pathogenesis of atherosclerosis, and the search for other risk factors continues on the medical horizon. Renin-angiotensin system (RAS), a multienzyme, multilocale axis, has been extensively studied as an important mediator of atherosclerosis. Recently, the tissue-based angiotensin system has been suggested as the most significant pathway of RAS. A genetic polymorphism in the human gene for the angiotensin-converting enzyme (ACE), one of the two enzymes of RAS, has been found to have a strong association with higher risk for acute coronary events, sudden cardiac death, vascular restenosis after angioplasty, and idiopathic and hypertrophic cardiomyopathy. Clinical and animal data support angiotensin II to be the final common pathway in the enzyme cascade of RAS and ACE as the key enzyme in the generation of Angiotensin II. ACE gene polymorphism appears to modify expression of cellular and free ACE levels and could represent a genetic marker for cardiovascular disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 64 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 09:33:45 EST