C-reactive protein and cardiovascular diseases-Is it ready for primetime?

Lavie, Carl J., Milani, Richard V., Verma, Anil and O'Keefe, James H. (2009) C-reactive protein and cardiovascular diseases-Is it ready for primetime?. American Journal of The Medical Sciences, 338 6: 486-492. doi:10.1097/MAJ.0b013e3181c61b66


Author Lavie, Carl J.
Milani, Richard V.
Verma, Anil
O'Keefe, James H.
Title C-reactive protein and cardiovascular diseases-Is it ready for primetime?
Journal name American Journal of The Medical Sciences   Check publisher's open access policy
ISSN 0002-9629
1538-2990
Publication date 2009-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MAJ.0b013e3181c61b66
Volume 338
Issue 6
Start page 486
End page 492
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Wiliams & Wilkins
Language eng
Abstract C-reactive protein (CRP) is a marker of systemic inflammation, and it has been implicated in the pathogenesis of many chronic diseases, including cardiovascular (CV) diseases. With highly sensitive CRP assays, serum CRP can add considerably to standard coronary heart disease risk factors and in the prediction of subsequent major CV risk. We review evidence supporting the assessment of highly sensitive CRP both in patients with established CV diseases and in those without known disease as well as evidence supporting CRP as a target of therapy. We also review various pharmacologic (especially intensive statin therapy) and nonpharmacologic therapies to reduce levels of CRP.
Keyword C-reactive protein
Risk factor
Cardiovascular disease
Coronary heart disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:31:43 EST