Obesity and Cardiovascular Disease Risk Factor, Paradox, and Impact of Weight Loss

Lavie, Carl J., Milani, Richard V. and Ventura, Hector O. (2009) Obesity and Cardiovascular Disease Risk Factor, Paradox, and Impact of Weight Loss. Journal of the American College of Cardiology, 53 21: 1925-1932. doi:10.1016/j.jacc.2008.12.068

Author Lavie, Carl J.
Milani, Richard V.
Ventura, Hector O.
Title Obesity and Cardiovascular Disease Risk Factor, Paradox, and Impact of Weight Loss
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
ISSN 0735-1097
Publication date 2009-05
Sub-type Article (original research)
DOI 10.1016/j.jacc.2008.12.068
Volume 53
Issue 21
Start page 1925
End page 1932
Total pages 8
Place of publication San Diego, CA, United States
Publisher Elsevier
Language eng
Abstract Obesity has reached global epidemic proportions in both adults and children and is associated with numerous comorbidities, including hypertension (HTN), type II diabetes mellitus, dyslipidemia, obstructive sleep apnea and sleep-disordered breathing, certain cancers, and major cardiovascular (CV) diseases. Because of its maladaptive effects on various CV risk factors and its adverse effects on CV structure and function, obesity has a major impact on CV diseases, such as heart failure (HF), coronary heart disease (CHD), sudden cardiac death, and atrial fibrillation, and is associated with reduced overall survival. Despite this adverse association, numerous studies have documented an obesity paradox in which overweight and obese people with established CV disease, including HTN, HF, CHD, and peripheral arterial disease, have a better prognosis compared with nonoverweight/nonobese patients. This review summarizes the adverse effects of obesity on CV disease risk factors and its role in the pathogenesis of various CV diseases, reviews the obesity paradox and potential explanations for these puzzling data, and concludes with a discussion regarding the current state of weight reduction in the prevention and treatment of CV diseases.
Keyword obesity
cardiovascular disease
weight loss
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 09:30:56 EST