Omega-3 polyunsaturated fatty acids and cardiovascular diseases

Lavie, Carl J., Milani, Richard V., Mehra, Mandeep R. and Ventura, Hector O. (2009) Omega-3 polyunsaturated fatty acids and cardiovascular diseases. Journal of the American College of Cardiology, 54 7: 585-594. doi:10.1016/j.jacc.2009.02.084

Author Lavie, Carl J.
Milani, Richard V.
Mehra, Mandeep R.
Ventura, Hector O.
Title Omega-3 polyunsaturated fatty acids and cardiovascular diseases
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
ISSN 0735-1097
Publication date 2009-08-11
Sub-type Article (original research)
DOI 10.1016/j.jacc.2009.02.084
Volume 54
Issue 7
Start page 585
End page 594
Total pages 10
Place of publication San Diego, CA, United States
Publisher Elsevier
Language eng
Abstract Omega-3 polyunsaturated fatty acid (ω-3 PUFA) therapy continues to show great promise in primary and, particularly in secondary prevention of cardiovascular (CV) diseases. The most compelling evidence for CV benefits of ω-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF). We discuss the evidence from retrospective epidemiologic studies and from large randomized controlled trials showing the benefits of ω-3 PUFA, specifically EPA and DHA, in primary and secondary CV prevention and provide insight into potential mechanisms of these observed benefits. The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF. Further studies are needed to determine optimal dosing and the relative ratio of DHA and EPA ω-3 PUFA that provides maximal cardioprotection in those at risk of CV disease as well in the treatment of atherosclerotic, arrhythmic, and primary myocardial disorders.
Keyword Cardiovascular diseases
Fish oils
Omega-3 polyunsaturated fatty acids
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 258 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 316 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 09:29:38 EST