Factors associated with the recommendation for endocarditis prophylaxis in mitral valve prolapse

Lavie, C. J., Khandheria, B. K., Seward, J. B., Tajik, J., Taylor, C. L. and Ballard, D. J. (1989) Factors associated with the recommendation for endocarditis prophylaxis in mitral valve prolapse. Journal of the American Medical Association, 262 23: 3308-3312. doi:10.1001/jama.262.23.3308

Author Lavie, C. J.
Khandheria, B. K.
Seward, J. B.
Tajik, J.
Taylor, C. L.
Ballard, D. J.
Title Factors associated with the recommendation for endocarditis prophylaxis in mitral valve prolapse
Journal name Journal of the American Medical Association   Check publisher's open access policy
ISSN 0098-7484
Publication date 1989-12
Sub-type Article (original research)
DOI 10.1001/jama.262.23.3308
Volume 262
Issue 23
Start page 3308
End page 3312
Total pages 5
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract We conducted a population-based study to examine the association between clinical and Doppler echocardiographic characteristics and physicians' recommendation for endocarditis prophylaxis. Of 127 consecutive Olmsted County, Minnesota, residents with newly documented isolated mitral valve prolapse, endocarditis prophylaxis was recommended three to four times more often in patients under 40 years compared with those more than 60 years of age. Using multiple logistic regression, for every 10-year increment in age, there was a 30% independent reduction in recommendations for endocarditis prophylaxis. Doppler evidence of mitral regurgitation was also independently associated with recommendations for endocarditis prophylaxis. Observations from physical examination, including systolic murmur and systolic click, were weakly associated with endocarditis prophylaxis recommendations. Mitral valve appearance (thickened vs not) was not associated with endocarditis prophylaxis. Although current recommendations for endocarditis prophylaxis and mitral valve prolapse do not address age and Doppler-detected mitral regurgitation, these variables are strongly associated with clinical decisions. Prospective, longitudinal, population-based studies are needed to define endocarditis risk further in subgroups with mitral valve prolapse to provide a more scientific basis for clinical decision making.
Keyword Endocarditis prophylaxis
Mitral valve prolapse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Mar 2011, 09:25:23 EST