The importance of recognizing and treating low levels of high-density lipoprotein cholesterol: A new era in atherosclerosis management

Cardenas, G. A., Lavie, C. J., Cardenas, V., Milani, R. V. and McCullough, P. A. (2008) The importance of recognizing and treating low levels of high-density lipoprotein cholesterol: A new era in atherosclerosis management. Reviews in Cardiovascular Medicine, 9 4: 239-258.

Author Cardenas, G. A.
Lavie, C. J.
Cardenas, V.
Milani, R. V.
McCullough, P. A.
Title The importance of recognizing and treating low levels of high-density lipoprotein cholesterol: A new era in atherosclerosis management
Journal name Reviews in Cardiovascular Medicine   Check publisher's open access policy
ISSN 1530-6550
2153-8174
Publication date 2008-10
Sub-type Critical review of research, literature review, critical commentary
Volume 9
Issue 4
Start page 239
End page 258
Total pages 20
Place of publication New York, NY, United States
Publisher MedReviews
Language eng
Formatted abstract
Low levels of high-density lipoprotein cholesterol (HDL-C) represent a major cardiovasa lar risk factor, with a stronger relationship to coronary heart disease than that seen wit) elevated levels of low-density lipoprotein cholesterol (LDL-C). HDL-C has important an tiatherogenic effects, including reverse cholesterol transport, inhibition of LDL-C oxidation, and antiplatelet and anti-inflammatory actions. Patients with low HDL-C are ah at an amplified risk of coronary heart disease due to the common coexistence of other risk factors, including excess adiposity, metabolic syndrome, type 2 diabetes mellitus, hypertriglyceridemia, and the atherogenic dyslipidemia characterized by small dense LDL-C. First-line therapy of low HDL-C generally consists of nonpharmacologic measures such as improved fitness and weight loss. Current pharmaceutical options include statins, fibrates, and nicotinic acid. A host of novel approaches involving HDL-C and reverse cholesterol transport hold the promise of fundamentally changing the natural history of atherosclerosis, the most common and important chronic disease in humans.
Keyword Atherosclerosis
High-density lipoprotein cholesterol
Dyslipidemia
Reverse cholesterol transport system
Cholesteryl ester transfer protein
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:22:36 EST