Development of a serum profile for healthy aging

Byerley, Lauri O., Leamy, Larry, Tam, Sun W., Chou, Chau-Wen, Ravussin, Eric, For the Louisiana Healthy Aging Study and Lavie, Carl (2010) Development of a serum profile for healthy aging. Age, 32 4: 497-507. doi:10.1007/s11357-010-9146-8


Author Byerley, Lauri O.
Leamy, Larry
Tam, Sun W.
Chou, Chau-Wen
Ravussin, Eric
For the Louisiana Healthy Aging Study
Lavie, Carl
Title Development of a serum profile for healthy aging
Journal name Age   Check publisher's open access policy
ISSN 0161-9152
1574-4647
Publication date 2010-12
Sub-type Article (original research)
DOI 10.1007/s11357-010-9146-8
Volume 32
Issue 4
Start page 497
End page 507
Total pages 11
Place of publication Dordrecht, Germany
Publisher Springer Netherlands
Collection year 2011
Language eng
Formatted abstract
Increasing numbers of Americans are reaching 85 years of age or older, yet there are no reliable biomarkers to predict who will live this long. The goal of this pilot study therefore was: (1) to identify a potential serum pattern that could identify proteins involved in longevity and (2) to determine if this pattern was a marker of longevity in an independent sample of individuals. Serum samples were analyzed in three cohorts of individuals (n = 12 in each) aged 20–34, 60–74, and ≥90 years who participated in The Louisiana Healthy Aging Study. The 12 most abundant proteins were removed and the remaining proteins separated by two-dimensional gel electrophoresis. Gels were matched and the intensity of each spot quantified. Multivariate discriminant analysis was used to identify a serum pattern that could separate these three age cohorts. Seven protein spots were found that correctly distinguished the subjects into the three groups. However, these spots were not as successful in discriminating the ages in a second set of 15 individuals as only eight of these subjects were placed into their correct group. These preliminary results show that the proteomics approach can be used to identify potential proteins or markers that may be involved in the aging process and/or be important determinants of longevity.
Keyword Aging
Serum
Proteomics
Biomarkers
Longevity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:22:30 EST