Effects of aerobic exercise training on indices of ventricular repolarization in patients with chronic heart failure

Ali, Arshad, Mehra, Mandeep R., Malik, Furrukh S., Lavie, Carl J., Bass, Donna and Milani, Richard V. (1999). Effects of aerobic exercise training on indices of ventricular repolarization in patients with chronic heart failure. In: 70th Annual Scientific Assembly of the American-Heart-Association, Orlando, FL, United States, (83-87). 9-12 November 1997. doi:10.1378/chest.116.1.83


Author Ali, Arshad
Mehra, Mandeep R.
Malik, Furrukh S.
Lavie, Carl J.
Bass, Donna
Milani, Richard V.
Title of paper Effects of aerobic exercise training on indices of ventricular repolarization in patients with chronic heart failure
Conference name 70th Annual Scientific Assembly of the American-Heart-Association
Conference location Orlando, FL, United States
Conference dates 9-12 November 1997
Journal name Chest   Check publisher's open access policy
Place of Publication Northbrook, IL, United States
Publisher American College of Chest Physicians
Publication Year 1999
Sub-type Fully published paper
DOI 10.1378/chest.116.1.83
ISSN 0012-3692
1931-3543
Volume 116
Issue 1
Start page 83
End page 87
Total pages 4
Language eng
Formatted Abstract/Summary
Background: Patients with chronic heart failure (CHF) have a markedly increased incidence of malignant ventricular arrhythmias. QT dispersion (QTd), defined as the difference between maximal and minimal QT intervals, reflects the regional inhomogeneity of ventricular repolarization dispersion and may mark the presence of malignant ventricular arrhythmias.

Purpose: To determine the effects of exercise training on QTd in patients with CHF.

Patients: Fifteen patients with CHF and ejection fractions < 40% (mean, 28 ± 9%) who were on a stable medical regimen.

Design and intervention: Standardized 12-lead surface ECGs were obtained at the beginning and end of the exercise training program, and QT and JT intervals were measured manually and corrected for heart rate by using Bazett's formula. QTd, heart rate- corrected QTd (QTc-d), JT dispersion (JTd), and heart rate-corrected JTd (JTc-d) were measured in at least eight ECG leads in each patient.

Results: Following the cardiac rehabilitation and exercise training programs, patients with CHF had only slight improvements in exercise capacity (results were not significant). However, these patients had marked improvements in QTd (71 ± 11 to 59 ± 17 ms; p < 0.02), QTc-d (82 ± 28 to 63 ± 17 ms; p < 0.01), JTd (76 ± 19 to 57 ± 18 ms; p < 0.002), and JTc-d (84 ± 23 to 61 ± 18 ms; p < 0.001) following the exercise training programs.

Conclusion: These data indicate that aerobic exercise training significantly reduces the indices of ventricular repolarization dispersion in patients with CHF. Further studies are needed to evaluate how effectively this reduction in ventricular repolarization dispersion decreases the risk of malignant ventricular arrhythmias and sudden death in patients with CHF.
Keyword Arrhythmias
Exercise training
Heart failure
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 09:21:14 EST