Evaluation of the efficacy and safety of outpatient parenteral antimicrobial therapy for infections with methicillin-sensitive Staphylococcus aureus

Wynn, Melissa, Dalovisio, Joseph R., Tice, Alan D. and Jiang, Xiaozhang (2005). Evaluation of the efficacy and safety of outpatient parenteral antimicrobial therapy for infections with methicillin-sensitive Staphylococcus aureus. In: Southern Medical Journal. 40th Annual Meeting of the Infectious Diseases Society of America, Chicago, IL, United States, (590-595). 24-27 October 2002. doi:10.1097/01.SMJ.0000145300.28736.BB


Author Wynn, Melissa
Dalovisio, Joseph R.
Tice, Alan D.
Jiang, Xiaozhang
Title of paper Evaluation of the efficacy and safety of outpatient parenteral antimicrobial therapy for infections with methicillin-sensitive Staphylococcus aureus
Conference name 40th Annual Meeting of the Infectious Diseases Society of America
Conference location Chicago, IL, United States
Conference dates 24-27 October 2002
Proceedings title Southern Medical Journal   Check publisher's open access policy
Journal name Southern Medical Journal   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Publication Year 2005
Sub-type Fully published paper
DOI 10.1097/01.SMJ.0000145300.28736.BB
ISSN 0038-4348
1541-8243
Volume 98
Issue 6
Start page 590
End page 595
Total pages 5
Language eng
Formatted Abstract/Summary
Objectives: As increasing numbers of patients are being treated with outpatient parenteral antimicrobial therapy (OPAT), it becomes ever more important to ascertain the risks and benefits of such treatment for patients.


Methods: We conducted a retrospective analysis of 1,515 patients with methicillin-sensitive Staphylococcus aureus infections who were treated with outpatient parenteral antimicrobial monotherapy. All patients were included in the adverse drug reaction analysis; 1,252 were evaluable for purposes of evaluating treatment efficacy.


Results: The six antibiotics most frequently used in this study (ceftriaxone, cefazolin, vancomycin, oxacillin, nafcillin, and clindamycin) appeared to be equivalent in achieving the desired efficacy outcome.


Conclusions: Vancomycin was associated with a significantly greater number of side effects than was ceftriaxone, cefazolin, or oxacillin, and nafcillin was associated with a significantly greater number of adverse events than ceftriaxone.
Keyword ceftriaxone
outpatient parenteral antimicrobial therapy
skin infections
Staphylococcus aureus
vancomycin
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
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Created: Mon, 14 Mar 2011, 19:17:33 EST