Induction with rabbit antithymocyte globulin versus induction with corticosteroids in liver transplantation: Impact on recurrent hepatitis C virus infection

Nair, Satheesh, Loss, George E., Cohen, Ari J. and Eason, Jason D. (2006) Induction with rabbit antithymocyte globulin versus induction with corticosteroids in liver transplantation: Impact on recurrent hepatitis C virus infection. Transplantation, 81 4: 620-622. doi:10.1097/01.tp.0000181192.13836.8c


Author Nair, Satheesh
Loss, George E.
Cohen, Ari J.
Eason, Jason D.
Title Induction with rabbit antithymocyte globulin versus induction with corticosteroids in liver transplantation: Impact on recurrent hepatitis C virus infection
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
1534-6080
Publication date 2006-02-01
Sub-type Article (original research)
DOI 10.1097/01.tp.0000181192.13836.8c
Volume 81
Issue 4
Start page 620
End page 622
Total pages 3
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract This study compares the clinical course of recurrent hepatitis C virus (HCV) infection between 64 patients, who were randomized to receive either rabbit antithymocyte globulin (RATG) or steroids as induction therapy with tacrolimus for maintenance. The HCV recurrence was assessed by HCV RNA levels, peak ALT at 3-6 months, the grade of inflammation at biopsy at 3-6 months posttransplant, progression of fibrosis, and survival. All patients had also received antiviral therapy with interferon alpha 2b and ribavirin, if there were no contraindications. There was no statistically significant difference between the two groups in terms of inflammation at 3 months, peak ALT, or HCV RNA. The survival between the two groups of patients was similar. It appears that steroid-free liver transplantation with RATG induction does not have any negative influence on HCV recurrence in hepatitis C patients after liver transplantation.
Keyword hepatitis C
liver transplantation
rabbit antithymocyte globulin
steroid-free immunosuppression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 33 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 18:51:50 EST