The relationship between bone mineral density and biomechanics in patients with osteoporosis and scoliosis

Routh, R. Hank, Rumancik, Sara, Pathak, Ram D., Burshell, Alan L. and Nauman, Eric A. (2005) The relationship between bone mineral density and biomechanics in patients with osteoporosis and scoliosis. Osteoporosis International, 16 12: 1857-1863. doi:10.1007/s00198-005-1951-z


Author Routh, R. Hank
Rumancik, Sara
Pathak, Ram D.
Burshell, Alan L.
Nauman, Eric A.
Title The relationship between bone mineral density and biomechanics in patients with osteoporosis and scoliosis
Journal name Osteoporosis International   Check publisher's open access policy
ISSN 0937-941X
1433-2965
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1007/s00198-005-1951-z
Volume 16
Issue 12
Start page 1857
End page 1863
Total pages 7
Place of publication Surrey, United Kingdom
Publisher Springer
Language eng
Abstract Nearly one-third of all women and one-sixth of all men over age 65 have osteoporosis, and this condition is often accompanied by lumbar scoliosis. Previous work has shown that, in a group of postmenopausal women with scoliosis and osteoporosis, both the bone mineral content (BMC) and bone mineral density (BMD) were greater on the concave side than the convex side. The goal of this study was to examine the structure-function relationships in the spines of patients with low bone mass and scoliosis using a patient-specific biomechanical model. We compared the percent change in BMC and the percent change in BMD with axial force, Fa, shear force, Fs, moment, M, local curvature, θrel, and the patient's age, A. We found that the percent change in BMC depended on the applied moment and the local curvature. The same dependence was observed for the percent change in BMD, but in this case, the shear force was also significantly inversely correlated. A population with femoral neck BMD with a T-score greater than -2.0 was similarly evaluated and yielded similar results. The percent change in BMD was related to M, θrel, A and negatively to the shear force. These results indicate that the osteoporotic spine is still able to respond to changes in the mechanical environment and provides a useful comparison between patients with osteoporosis and those with normal bone mass. In addition, this model may be a useful tool for the in vivo assessment of bone density changes in response to mechanical stimuli and drug treatments.
Keyword biomechanical model
bone adaptation
vertebral deformity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 08:50:02 EST