An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: Possible hormone receptor system

Feldman, D., Do, Y., Burshell, A., Stathis, P. and Loose, D. S. (1982) An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: Possible hormone receptor system. Science, 218 4569: 297-298. doi:10.1126/science.6289434


Author Feldman, D.
Do, Y.
Burshell, A.
Stathis, P.
Loose, D. S.
Title An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: Possible hormone receptor system
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 1982
Sub-type Article (original research)
DOI 10.1126/science.6289434
Volume 218
Issue 4569
Start page 297
End page 298
Total pages 2
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17β-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 08:49:31 EST