Genetic variation of the APOE promoter and outcome after head injury

Lendon, C. L., Harris, J. M., Pritchard, A. L., Nicoll, J. A. R., Teasdale, G. M. and Murray, G. (2003) Genetic variation of the APOE promoter and outcome after head injury. Neurology, 61 5: 683-685.


Author Lendon, C. L.
Harris, J. M.
Pritchard, A. L.
Nicoll, J. A. R.
Teasdale, G. M.
Murray, G.
Title Genetic variation of the APOE promoter and outcome after head injury
Journal name Neurology   Check publisher's open access policy
ISSN 0028-3878
1526-632X
Publication date 2003-09
Sub-type Article (original research)
Volume 61
Issue 5
Start page 683
End page 685
Total pages 3
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract The APOE-ε4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 08:01:33 EST