Investigation of the neural control of cough and cough suppression in humans using functional brain imaging

Mazzone, Stuart B., Cole, Leonie J., Ando, Ayaka, Egan, Gary F. and Farrell, Michael J. (2011) Investigation of the neural control of cough and cough suppression in humans using functional brain imaging. Journal of Neuroscience, 31 8: 2948-2958. doi:10.1523/JNEUROSCI.4597-10.2011

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Author Mazzone, Stuart B.
Cole, Leonie J.
Ando, Ayaka
Egan, Gary F.
Farrell, Michael J.
Title Investigation of the neural control of cough and cough suppression in humans using functional brain imaging
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2011-02-23
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4597-10.2011
Open Access Status File (Publisher version)
Volume 31
Issue 8
Start page 2948
End page 2958
Total pages 11
Place of publication United States
Publisher Society for Neuroscience
Collection year 2012
Language eng
Abstract Excessive coughing is one of the mostcommonreasons for seeking medical advice, yet the available therapies for treating cough disorders are inadequate. Humans can voluntarily cough, choose to suppress their cough, and are acutely aware of an irritation that is present in their airways. This indicates a significant level of behavioral and conscious control over the basic cough reflex pathway. However, very little is known about the neural basis for higher brain regulation of coughing. The aim of the present study was to use functional brain imaging in healthy humans to describe the supramedullary control of cough and cough suppression. Our data show that the brain circuitry activated during coughing in response to capsaicin-evoked airways irritation is not simply a function of voluntarily initiated coughing and the perception of airways irritation. Rather, activations in several brain regions, including the posterior insula and posterior cingulate cortex, define the unique attributes of an evoked cough. Furthermore, the active suppression of irritant-evoked coughing is also associated with a unique pattern of brain activity, including an involvement of the anterior insula, anterior mid-cingulate cortex, and inferior frontal gyrus. These data demonstrate for the first time that evoked cough is not solely a brainstem-mediated reflex response to irritation of the airways, but rather requires active facilitation by cortical regions, and is further regulated by distinct higher order inhibitory processes. Copyright © 2011 the authors.
Keyword Cingulate cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
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Created: Sun, 13 Mar 2011, 00:11:12 EST