在體內和體外的全身老化和複製衰老

Zhao, Liang, Zhang, Zong Yo and Tong, Tan Jun (2000) 在體內和體外的全身老化和複製衰老. 生理科學進展, 31 3: 205-210.

Author Zhao, Liang
Zhang, Zong Yo
Tong, Tan Jun
Title 在體內和體外的全身老化和複製衰老
Translated title Systemic aging and replicative senescence: In vivo and in vitro
Language of Title chi
Journal name 生理科學進展   Check publisher's open access policy
Translated journal name Progress in Physiological Sciences
Language of Journal Name chi
Publication date 2000-07
Sub-type Article
Volume number 31
Issue number 3
ISSN 0559-7765
Start page 205
End page 210
Total pages 6
Place of publication Beijing, China
Publisher Zhongguo Shengli Xuehui
Language chi
Abstract Cultured cells lose the ability of DNA synthesis, mitosis, and finally the ability of cell proliferation after they have undergone a finite number of population doublings in vitro, though the cells still maintain the basic metabolic process. This is termed replicative senescence. We review the prevalence of replicative senescence, summarize the features of senescent cells, and then focus on the links between systemic aging and replicative senescence. The present knowledge, albeit still incomplete, proposes that replicative senescence is a reflection of systemic aging at cell level, and it fully confirms replicative senescence as a good model for the research of systemic aging.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Fri, 11 Mar 2011, 15:05:08 EST by Susan Allen on behalf of Institute for Molecular Bioscience