Is Penicillium citrinum implicated in sago hemolytic disease?

Atagazli, Latifeh, Greenhill, Andrew R., Melrose, Wayne, Pue, Aisak G. and Warner, Jeffrey M. (2010) Is Penicillium citrinum implicated in sago hemolytic disease?. Southeast Asian Journal of Tropical Medicine and Public Health, 41 3: 641-646.

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Name Description MIMEType Size Downloads
Author Atagazli, Latifeh
Greenhill, Andrew R.
Melrose, Wayne
Pue, Aisak G.
Warner, Jeffrey M.
Title Is Penicillium citrinum implicated in sago hemolytic disease?
Formatted title
Is Penicillium citrinum implicated in sago haemolytic disease?
Journal name Southeast Asian Journal of Tropical Medicine and Public Health   Check publisher's open access policy
ISSN 0125-1562
Publication date 2010-05
Sub-type Article (original research)
Volume 41
Issue 3
Start page 641
End page 646
Total pages 6
Place of publication Bangkok, Thailand
Publisher Southeast Asian Ministers of Education Organisation
Collection year 2011
Language eng
Formatted abstract
Sago hemolytic disease (SHD) is an acute hemolytic syndrome affecting rural Papua New Guineans who depend on the starch of Metroxylon sagu as a staple carbohydrate. It is a suspected mycotoxicosis associated with fungal succession in stored and perhaps poorly fermented sago. Despite a mortality rate of approximately 25%, little is know about the disease. Recent studies have identified Penicillium citrinum as a possible candidate in the etiology of SHD. This is based on the frequency of isolation from sago starch and the hemolytic nature of the organism as demonstrated when cultured on sheep and human blood agar. A highly non-polar lipophilic P. citrinum fraction from C18 solid phase extraction demonstrated high hemolytic activity in a semi-quantitative assay using both mouse and human erythrocytes. When the red cell membrane proteins were subjected to sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separation, cleavage of protein band 3 and spectrin was demonstrated. This breach of major structural red cell proteins is consistent with the severe hemolysis found in vivo. Our findings warrant further investigation into the hemolytic activity of P. citrinum and its role as the etiological agent of SHD.
Keyword Penicillium citrinum
Sago hemolytic disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
National Research Centre for Environmental Toxicology Publications
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Created: Fri, 11 Mar 2011, 14:16:15 EST by Manjit Sanghera on behalf of National Res Centre For Environmental Toxicology