Combining autofluorescence and narrow band imaging with image analysis in the evaluation of preneoplastic lesions in the bronchus and larynx

Nguyen, Phan Tien, Salvado, Olivier, Masters, Ian Brent, Farah, Camile S. and Fielding, David (2010) Combining autofluorescence and narrow band imaging with image analysis in the evaluation of preneoplastic lesions in the bronchus and larynx. Journal of Bronchology & Interventional Pulmonology, 17 2: 109-116. doi:10.1097/LBR.0b013e3181da2ca8


Author Nguyen, Phan Tien
Salvado, Olivier
Masters, Ian Brent
Farah, Camile S.
Fielding, David
Title Combining autofluorescence and narrow band imaging with image analysis in the evaluation of preneoplastic lesions in the bronchus and larynx
Journal name Journal of Bronchology & Interventional Pulmonology   Check publisher's open access policy
ISSN 1070-8030
Publication date 2010-04
Sub-type Article (original research)
DOI 10.1097/LBR.0b013e3181da2ca8
Volume 17
Issue 2
Start page 109
End page 116
Total pages 8
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2011
Language eng
Formatted abstract
Background and Objectives:
Autofluorescence (AF) techniques improve the diagnostic yield of white light inspection for preneoplastic lesions in the bronchus and head and neck region. Although highly sensitive, AF has poor specificity, particularly in situations where there have been earlier biopsies or treatments such as radiotherapy. Narrow band imaging (NBI) is a newer imaging technique that enhances the early abnormal angiogenesis seen in preneoplastic lesions. NBI has higher specificity when compared with AF. We aimed to combine these imaging modalities, using AF as an effective screening tool and NBI to confirm AF findings. We also used computer-assisted image analysis techniques to give objective confirmation to our visual inspection.

Methods:
Three patients were selected for image analysis of their NBI images using the L*a*b* color scale in manually drawn regions of interest of biopsy-confirmed areas. Each case compared pathology with a different benign condition: normal tissue, postbiopsy effect, and postradiation therapy change. Patients had white light followed by AF inspection. Abnormal areas of AF were cross-examined with NBI.

Results:
NBI clearly showed dysplasia and carcinoma in situ. It also confirmed abnormal fluorescence because of earlier biopsies and radiation therapy. Analysis of the L*a*b* color space scale in each case showed segmentation between pathology and the benign tissue.

Conclusions:
There may be additive and discriminatory benefits of NBI after AF inspection. Further study with computer-assisted color segmentation techniques and image analysis is required before optical diagnosis can become a reality in bronchoscopic techniques in the future. © 2010 Lippincott Williams & Wilkins.
Keyword Autofluorescence
Endobronchial dysplasia
Image analysis
L*a*b*
Narrow band imaging
Optical biopsy
Optical diagnosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Dentistry Publications
 
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Created: Fri, 11 Mar 2011, 12:58:35 EST by Associate Professor Camile Farah on behalf of School of Dentistry