Urinary arsenic speciation profiles in mice subchronically exposed to low concentrations of sodium arsenate in drinking water

Wu, Huijie, Krishnamohan, Manonmanii, Lam, Paul Kwan Sing and Ng, Jack Chakmeng (2011) Urinary arsenic speciation profiles in mice subchronically exposed to low concentrations of sodium arsenate in drinking water. Kaohsiung Journal of Medical Sciences, 27 9: 417-423. doi:10.1016/j.kjms.2011.05.010


Author Wu, Huijie
Krishnamohan, Manonmanii
Lam, Paul Kwan Sing
Ng, Jack Chakmeng
Title Urinary arsenic speciation profiles in mice subchronically exposed to low concentrations of sodium arsenate in drinking water
Journal name Kaohsiung Journal of Medical Sciences   Check publisher's open access policy
ISSN 1607-551X
Publication date 2011-09
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.kjms.2011.05.010
Volume 27
Issue 9
Start page 417
End page 423
Total pages 7
Editor Wan-Long Chuang
Place of publication Singapore, Singapore
Publisher Elsevier (Singapore)
Collection year 2012
Language eng
Formatted abstract
Arsenic is a proven human carcinogen. Although the mechanism of its carcinogenicity is still largely unknown, methylation is thought to have an important role to play in arsenic toxicity. In this study, urinary methylation profiles were investigated in female C57BL/6J black mice given drinking water containing 500 μg arsenate (AsV)/L, 250 μg AsV/L, or 100 μg AsV/L as sodium arsenate for 2 months. The concentrations of arsenic chosen reflected those in the drinking water often encountered in arsenic-endemic areas. Urine samples were collected from the mice at the end of the exposure period, and the arsenic species were analyzed by high performance liquid chromatography-inductively coupled plasma-mass spectrometry. All detectable arsenic species showed strong linear correlation with the administered dosage. The methylation patterns were similar in all three groups with a slight decrease of dimethylarsinic acid/AsV ratio in the 500-μg/L group, which corresponded to the significantly higher arsenic retention in the tissue. The results indicate that urinary arsenic could be used as a good biomarker for internal dose and potential biological effects. Different doses of arsenic exposure could result in different degrees of methylation, excretion, and tissue retention, and this may contribute to the understanding of arsenic carcinogenicity.
Keyword Arsenic
Arsenic speciation
C57BL/6J mice
Drinking water
Methylation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes International Workshop on Updates in Arsenic-related Health Effects. Special Journal Issue.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
National Research Centre for Environmental Toxicology Publications
 
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Created: Fri, 11 Mar 2011, 10:50:16 EST by Manjit Sanghera on behalf of National Res Centre For Environmental Toxicology