Oxidative stress biomarkers as predictors of cardiovascular disease

Strobel, Natalie A., Fassett, Robert G., Marsh, Susan A. and Coombes, Jeff S. (2011) Oxidative stress biomarkers as predictors of cardiovascular disease. International Journal of Cardiology, 147 2: 191-201. doi:10.1016/j.ijcard.2010.08.008


Author Strobel, Natalie A.
Fassett, Robert G.
Marsh, Susan A.
Coombes, Jeff S.
Title Oxidative stress biomarkers as predictors of cardiovascular disease
Journal name International Journal of Cardiology   Check publisher's open access policy
ISSN 0167-5273
1874-1754
Publication date 2011-03-03
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.ijcard.2010.08.008
Volume 147
Issue 2
Start page 191
End page 201
Total pages 11
Editor Andrew J. S. Coats
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Collection year 2011
Language eng
Formatted abstract
Evidence for the role of oxidative stress in the pathogenesis of cardiovascular disease (CVD) is primarily based on experimental and observational human studies. The aim of this review is to examine the observational longitudinal studies that have investigated the relationship between oxidative stress biomarkers and CVD. Fifty-one studies were identified with twenty-six of these measuring oxidized (Ox)-LDL, fifteen assessing myeloperoxidase, seven using lipid peroxidation measures and three quantifying protein oxidation. Results of studies using Ox-LDL have been equivocal with sixteen of the twenty-six studies reporting that this measure is predictive of cardiovascular events. These inconsistent results are not explained by differences in the study populations (primary or secondary CVD) or the type of assay used (auto or monoclonal antibodies). Six of the seven lipid peroxidation, and two of three protein oxidation studies found associations. Twelve of fifteen studies assessing the role of myeloperoxidase reported it to be predictive of CVD. However, issues surrounding the specificity of myeloperoxidase as a marker of oxidative stress and the small number of research groups reporting these results, limit this finding. In summary, the ability of oxidative stress biomarkers to predict CVD has yet to be established. Furthermore, it is important to note that the methods used to assess oxidative stress in these studies are indirect, and the evidence that the various methods actually reflect oxidative stress in vivo is limited.
© 2010 Elsevier Ireland Ltd. All rights reserved.
Keyword Ox-LDL
Myeloperoxidase
Lipid peroxidation
Protein oxidation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 23 September 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Thu, 10 Mar 2011, 14:37:04 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences