Biomechanical transformation of the gastroc-soleus muscle with botulinum toxin A in children with cerebral palsy

Boyd, R. N., Pliatsios, V., Starr, R., Wolfe, R. and Graham, H. K. (2000) Biomechanical transformation of the gastroc-soleus muscle with botulinum toxin A in children with cerebral palsy. Developmental Medicine and Child Neurology, 42 1: 32-41. doi:10.1111/j.1469-8749.2000.tb00022.x


Author Boyd, R. N.
Pliatsios, V.
Starr, R.
Wolfe, R.
Graham, H. K.
Title Biomechanical transformation of the gastroc-soleus muscle with botulinum toxin A in children with cerebral palsy
Journal name Developmental Medicine and Child Neurology   Check publisher's open access policy
ISSN 0012-1622
1469-8749
Publication date 2000-01
Sub-type Article (original research)
DOI 10.1111/j.1469-8749.2000.tb00022.x
Volume 42
Issue 1
Start page 32
End page 41
Total pages 10
Language eng
Abstract Objective measures (kinematics and kinetics) were used to study prospectively the effects of botulinum toxin A (BTX/A) on the gastroc-soleus muscle in ambulant children with cerebral palsy. In this prospective before and after trial, 15 children with diplegia and 10 children with hemiplegia were studied (mean age 5 years 7 months, range 4 years to 9 years). A range of standardized clinical measures was undertaken but the emphasis for this report is on the three-dimensional gait analysis (3DGA) results. All children showed improvements in sagittal ankle kinematics, as has been previously reported. Two new measures of ankle kinetics were devised: ankle moment quotient (AMQ), and ankle power quotient (APQ). Before intervention, ankle moments were characterized by a 'double bump' ankle moment. A typical abnormal baseline ankle-power curve was triphasic with an initial trough of absorption followed by abnormal mid-stance power generation, instead of the usual A1 pattern, and reduced terminal stance power generation (A2). Three weeks after treatment with BTX/A alone there was a statistically significant improvement of AMQ and APQ; some patients required potentiation of BTX/A with a short period of serial casts. Both groups (BTX/A alone and BTX/A plus casting) continued to show improvement in ankle kinetics from baseline after 12 and 24 weeks. This is the first study to demonstrate improvements in the typical abnormal ankle kinetics which we believe provides evidence of the 'biomechanical transformation of muscle'.
Keyword DOUBLE-BLIND TRIAL
A TOXIN
MANAGEMENT
INJECTION
LIMB
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 10 Mar 2011, 10:15:41 EST