Tuberculosis and host metabolism: ancient associations, fresh insights

Blumenthal, Antje, Isovski, Flonza and Rhee, Kyu Y. (2009) Tuberculosis and host metabolism: ancient associations, fresh insights. Translational Research, 154 1: 7-14. doi:10.1016/j.trsl.2009.04.004


Author Blumenthal, Antje
Isovski, Flonza
Rhee, Kyu Y.
Title Tuberculosis and host metabolism: ancient associations, fresh insights
Journal name Translational Research   Check publisher's open access policy
ISSN 1931-5244
1532-6543
Publication date 2009-07
Sub-type Article (original research)
DOI 10.1016/j.trsl.2009.04.004
Volume 154
Issue 1
Start page 7
End page 14
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Epidemiologic studies have repeatedly identified malnutrition as a risk factor for tuberculosis (TB), which is the leading bacterial cause of deaths worldwide. The biologic basis for this association, however, remains unclear. Recent work has uncovered a large array of signaling molecules lying at the intersection of metabolic and immune signaling, among which nuclear hormone receptors (NHRs) and the insulin receptor have emerged as 2 prototypic examples. Existing knowledge indicates that the physiologic functions of many NHRs overlap with known epidemiologic risk factors for TB and that diabetes, itself, predisposes to TB. Here, we assimilate these data and identify a potential mechanism that may help to explain the long-standing clinical association between TB and host metabolism. Together, these data emphasize the underused potential of interdisciplinary dialog in current TB research efforts.
Keyword TUMOR-NECROSIS-FACTOR
INDUCED TYROSINE PHOSPHORYLATION
CULTURED HUMAN MACROPHAGES
VIRULENT TUBERCLE-BACILLI
ACTIVATED RECEPTOR-GAMMA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Thu, 10 Mar 2011, 10:00:56 EST