Local and global cytosolic Ca(2+) oscillations evoked by agonists and inositol trisphosphate

Petersen, Ole H., Thorn, Peter, Toescu, E. C., Lawrie, Alison M., Smith, Peter M., Petersen, C. C. H., Tepikin, A. V. and Gallacher, David V. (1993). Local and global cytosolic Ca(2+) oscillations evoked by agonists and inositol trisphosphate. In: 18th Seiriken Conference on Calcium Regulated Cellular Activities, Okazaki, Japan, (43-46). 2-4 March, 1993.

Author Petersen, Ole H.
Thorn, Peter
Toescu, E. C.
Lawrie, Alison M.
Smith, Peter M.
Petersen, C. C. H.
Tepikin, A. V.
Gallacher, David V.
Title of paper Local and global cytosolic Ca(2+) oscillations evoked by agonists and inositol trisphosphate
Formatted title
Local and global cytosolic Ca2+ oscillations evoked by agonists and inositol trisphosphate
Conference name 18th Seiriken Conference on Calcium Regulated Cellular Activities
Conference location Okazaki, Japan
Conference dates 2-4 March, 1993
Journal name Biomedical Research   Check publisher's open access policy
Place of Publication Sapporo, Japan
Publisher Biomedical Research Press
Publication Year 1993
Sub-type Fully published paper
Open Access Status Not Open Access
ISSN 0388-6107
1880-313X
Volume 14
Issue Supp. 2
Start page 43
End page 46
Total pages 4
Language eng
Formatted Abstract/Summary
The agonists acetylcholine (ACh) and cholecystokinin (CCK) evoke oscillating cytosolic Ca2+ signals in pancreatic acinar cells. Low agonist concentrations evoke local cytosolic Ca2+ spikes confined to the secretory pole region and intracellular inositol trisphosphate application can mimick this action. These spikes can occur alone, repetitively or precede longer lasting Ca2+ transients that spread throughout the cell. ACh and CCK evoke different Ca2+ signal patterns also influenced by the resting cytosolic Ca2+ concentration ([Ca2+](i)). Ca2+ pump-mediated Ca2+ extrusion occurs in a pulsatile manner and is synchronous with the transient elevations of [Ca2+](i).
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 10 Mar 2011, 08:46:47 EST