Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis

Crawford, D. H. G., Murphy, T. L., Ramm, L. E., Fletcher, L. M., Clouston, A. D., Anderson, G. J., Subramaniam, V. N., Powell, L. W. and Ramm, G. A. (2008). Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. In: Special Issue: Australian Gastroenterology Week. AGW 2008: Australian Gastroenterology Week 08, Brisbane, QLD, Australia, (A244-A244). 22-25 October 2008. doi:10.1111/j.1440-1746.2008.05613.x


Author Crawford, D. H. G.
Murphy, T. L.
Ramm, L. E.
Fletcher, L. M.
Clouston, A. D.
Anderson, G. J.
Subramaniam, V. N.
Powell, L. W.
Ramm, G. A.
Title of paper Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
Conference name AGW 2008: Australian Gastroenterology Week 08
Conference location Brisbane, QLD, Australia
Conference dates 22-25 October 2008
Proceedings title Special Issue: Australian Gastroenterology Week   Check publisher's open access policy
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
Publication Year 2008
Sub-type Published abstract
DOI 10.1111/j.1440-1746.2008.05613.x
ISSN 0815-9319
1440-1746
Volume 23
Issue Supp. 4
Start page A244
End page A244
Total pages 1
Language eng
Formatted Abstract/Summary
Background: The presence of cirrhosis is the most important determinant of survival in C282Y homozygous hereditary hemochromatosis (HH) and affected patients should undergo regular radiological and endoscopic surveillance. Only HH patients with serum ferritin >1000 μg/L are at risk of cirrhosis, however, the majority of these patients do not have cirrhosis. Non-invasive markers of hepatic fibrosis may assist in determining which patients with a serum ferritin concentration >1000 μg/L have cirrhosis and require liver biopsy for confirmation.

Conclusions: In HH, the measurement of hyaluronic acid in patients with serum ferritin >1000 μg/L is a non-invasive, accurate and cost-effective method for the diagnosis of cirrhosis.
© 2008 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 15:45:04 EST