Universal occurrence of glomerular abnormalities in patients receiving liver transplants

Crawford, D. H. G., Endre, Z. H., Axelsen, R. A., Lynch, S. V., Balderson, G. A., Strong, R. W., Kerlin, P., Powell, L. W. and Fleming, S. J. (1992) Universal occurrence of glomerular abnormalities in patients receiving liver transplants. American Journal of Kidney Diseases, 19 4: 339-344.

Author Crawford, D. H. G.
Endre, Z. H.
Axelsen, R. A.
Lynch, S. V.
Balderson, G. A.
Strong, R. W.
Kerlin, P.
Powell, L. W.
Fleming, S. J.
Title Universal occurrence of glomerular abnormalities in patients receiving liver transplants
Journal name American Journal of Kidney Diseases   Check publisher's open access policy
ISSN 0272-6386
Publication date 1992-04
Sub-type Article (original research)
Volume 19
Issue 4
Start page 339
End page 344
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Formatted abstract
We conducted a prospective study of renal histology and function in 18 consecutive nonalcoholic patients who underwent orthotopic liver transplantation (OLT). Despite well-preserved renal function, all patients had abnormal renal biopsies. Four patterns of glomerular injury were identified: minor glomerular abnormalities (eight patients), hepatic glomerulosclerosis (seven), membranoproliferative glomerulonephritis (one), and IgA nephropathy (one). In one patient there was insufficient tissue to allow classification. There was a trend toward lower plasma bilirubin and higher plasma albumin in patients with minor glomerular abnormalities than in the group of patients with more severe forms of glomerular injury (29 v 82 μmol/L, 35.5 v 30 g/L; P = 0.1, 0.1 > P > 0.05, respectively). Glomerular changes persisted in the three patients who died within 7 weeks post-OLT. IgM immunofluorescence was present in all biopsies and IgA in 11. IgM-containing circulating immune complexes occurred in five patients, suggesting a pathogenic role for IgM immune complex deposition. The significance of cirrhosis-associated glomerular abnormalities is not yet known. They may contribute to the hepatorenal syndrome and the renal dysfunction that occurs in up to 94% of patients post-OLT.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 15:44:17 EST