Dermatoglyphic a-b ridge count as a possible marker for developmental disturbance in schizophrenia: Replication in two samples

Fananas, L., van Os, J., Hoyos, C., McGrath, J., Mellor, C. S. and Murray, R. (1996) Dermatoglyphic a-b ridge count as a possible marker for developmental disturbance in schizophrenia: Replication in two samples. Schizophrenia Research, 20 3: 307-314. doi:10.1016/0920-9964(95)00013-5


Author Fananas, L.
van Os, J.
Hoyos, C.
McGrath, J.
Mellor, C. S.
Murray, R.
Title Dermatoglyphic a-b ridge count as a possible marker for developmental disturbance in schizophrenia: Replication in two samples
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 1996-07
Sub-type Article (original research)
DOI 10.1016/0920-9964(95)00013-5
Volume 20
Issue 3
Start page 307
End page 314
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The aim of this study was to conduct an epidemiological analysis of quantitative dermatoglyphic traits as a marker of prenatal disturbance during the second trimester of life in schizophrenic patients. TFRC (Total Finger Ridge Count) and TABRC (Total a-b Ridge Count) were studied in a sample of 38 schizophrenic patients and 69 healthy individuals. A significant decrease of the a-b ridge count was found in patients compared to controls, with a significant linear trend across the population distribution (OR linear trend = 1.6; 95% CI = 1.0-2.4), indicating that the effect was not confined to a subgroup of cases with values in the lowest range. This finding was replicated in a second, larger sample (OR linear trend = 1.3; 95% CI = 1.0-1.8). The suggestion that a-b ridge count is associated with genetic risk for schizophrenia needs to be investigated further. TFRC did not distinguish between patients and controls. The a-b ridge count may be a continuous risk factor for later schizophrenia, pointing towards a disturbance occurring during the second trimester of prenatal life, a period of critical CNS growth.
Keyword Schizophrenia
Dermatoglyphics
Development
Family history
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Wed, 09 Mar 2011, 15:34:01 EST