Heat stress lipids and schizophrenia

Bates, P. R., Hawkins, A., Mahadik, S. P. and McGrath, J. J. (1996). Heat stress lipids and schizophrenia. In: 2nd International Workshop on Cell Membrane Pathology in Schizophrenia, London, United Kingdom, (101-107). 6-8 October 1995. doi:10.1016/S0952-3278(96)90153-2

Author Bates, P. R.
Hawkins, A.
Mahadik, S. P.
McGrath, J. J.
Title of paper Heat stress lipids and schizophrenia
Conference name 2nd International Workshop on Cell Membrane Pathology in Schizophrenia
Conference location London, United Kingdom
Conference dates 6-8 October 1995
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
Place of Publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Publication Year 1996
Sub-type Fully published paper
DOI 10.1016/S0952-3278(96)90153-2
ISSN 0952-3278
Volume 55
Issue 1-2
Start page 101
End page 107
Total pages 6
Language eng
Abstract/Summary The neurodevelopmental hypothesis of schizophrenia implicates abnormal or disrupted neural growth during embryogenesis. It is postulated here that stress-inducing agents acting upon a compromised cellular system resulting from abnormal plasma membrane lipids could effect the neuronal abnormalities observed in schizophrenia. The heat stress response is induced by exposure to hyperthermia as well as a variety of other agents. The response to these agents includes the cessation of most transcriptional and translational activities, accompanied by the induction of a highly specific set of proteins. A concomitant reduction in metabolic activity including cell cycle delays is also observed. Much of the enormous literature on the heat stress response concentrates on protein and DNA interactions, especially with regard to transcriptional control. However, a variety of lipids are intrinsically involved in the heat stress response. This paper will provide a brief introduction to the heat shock proteins and will explore the roles that lipids play in the heat shock response.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: Queensland Brain Institute Publications
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Created: Wed, 09 Mar 2011, 15:32:50 EST