Reduced osmotic thirst in healthy elderly men

Phillips, P.A., Bretherton, M., Johnston, C.I. and Gray, L. (1991) Reduced osmotic thirst in healthy elderly men. American Journal of Physiology, 261 1: R166-R171.

Author Phillips, P.A.
Bretherton, M.
Johnston, C.I.
Gray, L.
Title Reduced osmotic thirst in healthy elderly men
Journal name American Journal of Physiology   Check publisher's open access policy
ISSN 0002-9513
Publication date 1991-07
Sub-type Article (original research)
Volume 261
Issue 1
Start page R166
End page R171
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
In response to water deprivation or heat stress, healthy elderly men experience reduced thirst compared with a young control group. Because water deprivation and heat stress produce hypertonicity as well as reduced extracellular fluid volume, the aim of this study was to determine whether the elderly also experience reduced thirst in response to hypertonicity without extracellular fluid volume depletion. To achieve this, after an overnight fast, healthy community-dwelling nonsmoking old (65-78 yr, n = 7) and young (20-32 yr, n = 7) men received 120-min hypertonic (0.855 M) and isotonic (0.154 M) saline infusions (0.06 ml· min-1·kg-1) in double-blind randomized order at least 2 wk apart. Both groups had increased thirst (P < 0.001) and water intake (P < 0.05) after the hypertonic saline infusion compared with the isotonic saline infusion. However, despite similar plasma sodium increases and less plasma volume expansion during the hypertonic saline infusion compared with the young group, the old group was less thirsty (P < 0.01) and drank less room-temperature tap water (young 11.1 ± 1.2 ml/kg, old 3.9 ± 0.6 ml/kg, P < 0.001). This reduced thirst in the old group seemed to be mainly due to a lower thirst sensitivity (P < 0.05) to hypertonicity, although there was also a tendency toward an increased thirst threshold. Plasma arginine vasopressin increases were similar for the old and young groups with hypertonic saline, without significant changes during the isotonic saline infusion in either group.
Keyword Hypertonicity
Arginine vasopressin
Water deprivation
Heat stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 15:25:08 EST