Signal transduction by the growth hormone receptor

Waters, M. J., Rowlinson, S. W., Clarkson, R. W., Chen, C. -M., Lobie, P. E., Norstedt, G., Mertani, H., Morel, G.,, Brinkworth, R., Wells, C. A., Bastiras, S., Robins, A. R., Muscat, G. E. and Barnard, R. T. (1994). Signal transduction by the growth hormone receptor. In: Workshop on the Superfamily of Receptors for Growth Hormone, Prolactin, Erythropoietin, and Cytokines, Haifa, Israel, (216-220). 7-11 November 1993.

Author Waters, M. J.
Rowlinson, S. W.
Clarkson, R. W.
Chen, C. -M.
Lobie, P. E.
Norstedt, G.
Mertani, H.
Morel, G.,
Brinkworth, R.
Wells, C. A.
Bastiras, S.
Robins, A. R.
Muscat, G. E.
Barnard, R. T.
Title of paper Signal transduction by the growth hormone receptor
Conference name Workshop on the Superfamily of Receptors for Growth Hormone, Prolactin, Erythropoietin, and Cytokines
Conference location Haifa, Israel
Conference dates 7-11 November 1993
Journal name Proceedings of the Society for Experimental Biology and Medicine   Check publisher's open access policy
Place of Publication London, United Kingdom
Publisher Royal Society of Medicine Press
Publication Year 1994
Sub-type Fully published paper
ISSN 0037-9727
1525-1373
Volume 206
Issue 3
Start page 216
End page 220
Total pages 4
Language eng
Abstract/Summary It has been proposed that dimerization of identical receptor subunits by growth hormone (GH) is the mechanism of signal transduction across the cell membrane. We present here data with analogs of porcine GH (pGH), with GH receptors (GHR) mutated in the dimerization domain and with monoclonal antibodies to the GHR which indicate that dimerization is necessary but not sufficient for transduction. We also report nuclear uptake of GH both in vivo and in vitro, along with nuclear localization of the receptor and GH-binding protein (GHBP). This suggests that GH acts directly at the nucleus, and one possible target for this action is a rapid increase in transcription of C/EBP delta seen in 3T3-F442A cells in response to GH. This tyrosine kinase- dependent event may be an archetype for induction of other immediate early gene transcription factors which then interact to determine the programing of the subsequent transcriptional response to GH.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

 
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