Eosinophil trafficking in allergy and asthma

Rosenberg, Helene F., Phipps, Simon and Foster, Paul S. (2007) Eosinophil trafficking in allergy and asthma. Journal of Allergy and Clinical Immunology, 119 6: 1303-1310. doi:10.1016/j.jaci.2007.03.048

Author Rosenberg, Helene F.
Phipps, Simon
Foster, Paul S.
Title Eosinophil trafficking in allergy and asthma
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2007-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jaci.2007.03.048
Volume 119
Issue 6
Start page 1303
End page 1310
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Blood eosinophilia and tissue eosinophilia are characteristic features of allergic inflammation and asthma, conditions associated with prominent production of TH2 cytokines IL-4, IL-5, and IL-13. In this review, we will consider recent advances in our understanding of the molecular mechanisms that promote expansion and differentiation of eosinophil progenitors in bone marrow, eosinophil recruitment in response to chemokine receptor 3 agonists eosinophil transit mediated by specific ligand-receptor interactions, and prolonged survival of eosinophils in peripheral tissues. Novel rational therapies including antiselectin and antichemokine receptor modalities designed to block eosinophil development and trafficking are discussed, together with the implications of recent clinical studies that have evaluated the efficacy of humanized anti–IL-5 mAb therapy.
Keyword Inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 179 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Mar 2011, 14:31:53 EST