A role for eosinophils in airway remodelling in asthma

Kay, A. B., Phipps, S. and Robinson, D. S. (2004) A role for eosinophils in airway remodelling in asthma. Trends in Immunology, 25 9: 477-482. doi:10.1016/j.it.2004.07.006

Author Kay, A. B.
Phipps, S.
Robinson, D. S.
Title A role for eosinophils in airway remodelling in asthma
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
Publication date 2004-09
Sub-type Article (original research)
DOI 10.1016/j.it.2004.07.006
Volume 25
Issue 9
Start page 477
End page 482
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of which is activated by epithelial-cell expression of the intergin α vβ 6. The emerging role for the eosinophil in airway remodelling might be important in future anti-asthma strategies. However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 156 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 186 times in Scopus Article | Citations
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Created: Wed, 09 Mar 2011, 14:29:54 EST