NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25

Kaiko, Gerard E., Phipps, Simon, Angkasekwinai, Pornpimon, Dong, Chen and Foster, Paul S. (2010) NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. Journal of Immunology, 185 8: 4681-4690. doi:10.4049/jimmunol.1001758

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Kaiko, Gerard E.
Phipps, Simon
Angkasekwinai, Pornpimon
Dong, Chen
Foster, Paul S.
Title NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1550-6606
Publication date 2010-10-15
Sub-type Article (original research)
DOI 10.4049/jimmunol.1001758
Volume 185
Issue 8
Start page 4681
End page 4690
Total pages 10
Place of publication Bethesda, MD, U.S.A.
Publisher American Association of Immunologists
Collection year 2011
Language eng
Formatted abstract
Severe respiratory syncytial virus (RSV) infection has long been associated with an increased risk for the development of childhood asthma and exacerbations of this disorder. Despite much research into the induction of Th2 responses by allergens and helminths, the factors associated with viral infection that predispose to Th2-regulated asthma remain unknown. Recently, clinical studies have shown reduced numbers of NK cells in infants suffering from a severe RSV infection. Here we demonstrate that NK cell deficiency during primary RSV infection of BALB/c mice results in the suppression of IFN-γ production and the development of an RSV-specific Th2 response and subsequent allergic lung disease. The outgrowth of the Th2 responses was dependent on airway epithelial cell-derived IL-25, which induced the upregulation of the notch ligand Jagged1 on dendritic cells. This study identifies a novel pathway underlying viral-driven Th2 responses that may have functional relevance to viral-associated asthma.
Copyright © 2010 by The American Association of Immunologists, Inc.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 59 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 09 Mar 2011, 14:29:41 EST