The effect of nasal hCT on bone turnover in Paget's disease of bone - Implications for the treatment of other metabolic bone diseases

Reginster, J. Y., Jeugmans-Huynen, A. M., Wouters, M., Sarlet, N., McIntyre, H. D. and Franchimont, P. (1992) The effect of nasal hCT on bone turnover in Paget's disease of bone - Implications for the treatment of other metabolic bone diseases. British Journal of Rheumatology, 31 1: 35-39.


Author Reginster, J. Y.
Jeugmans-Huynen, A. M.
Wouters, M.
Sarlet, N.
McIntyre, H. D.
Franchimont, P.
Title The effect of nasal hCT on bone turnover in Paget's disease of bone - Implications for the treatment of other metabolic bone diseases
Journal name British Journal of Rheumatology   Check publisher's open access policy
ISSN 0263-7103
Publication date 1992-01
Sub-type Article (original research)
Volume 31
Issue 1
Start page 35
End page 39
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Thirty pagetic patients were treated for 6 months with a daily nasal application of 2 mg of synthetic human calcitonin (hCT). Serum alkaline phosphatases (SAP) and urinary hydroxyproline/creatinine ratio (OH/Cr), reflecting bone turnover, were significantly reduced from the first month of treatment (mean ± SEM: SAP, -13.9 ± 2.2%; OH/Cr, -22.2 ± 5.8%; both P < 0.01) and until the end of the 6-month course (mean ± SEM: SAP, -29.7 ± 4.6%; OH/Cr, -22.5 ± 5.9%; both P < 0.01). Nasal hCT was perfectly tolerated both locally and systemically. These results allow us to consider nasal hCT for long-term trials in metabolic bone diseases characterized by a relative increase of bone resorption.
Keyword Calcitonin
Calcium
Osteoporosis
Paget's disease of bone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 14:27:47 EST