Molecular pathogenesis of pancreatic cancer

Hilgers, Werner, Rosty, Christophe and Hahn, Stephan A. (2002) Molecular pathogenesis of pancreatic cancer. Hematology/Oncology Clinics of North America, 16 1: 17-35. doi:10.1016/S0889-8588(01)00005-3

Author Hilgers, Werner
Rosty, Christophe
Hahn, Stephan A.
Title Molecular pathogenesis of pancreatic cancer
Journal name Hematology/Oncology Clinics of North America   Check publisher's open access policy
ISSN 0889-8588
Publication date 2002-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0889-8588(01)00005-3
Volume 16
Issue 1
Start page 17
End page 35
Total pages 19
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Abstract Our understanding of the biology of pancreatic carcinoma has greatly benefited from studies of the genetic alterations in this tumor type. The p16-CDK4-cyclinD-Rb pathway, the p53 tumor suppressor pathway, and the DPC4/Smad4 pathway are genetically inactivated in the majority of sporadic pancreatic carcinomas, whereas oncogenic K-ras signaling is almost ubiquitously activated. These genetic data have provided the basis to shape a first genetic progression model of this tumor type. Furthermore, a number of well define genetic syndromes which are associated with an inherited risk for pancreatic carcinoma have been identified recently.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Wed, 09 Mar 2011, 14:20:42 EST