Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent

Fournier, Laure S., Cuenod, Charles Andre, de Bazelaire, Cedric de, Siauve, Nathalie, Rosty, Christophe, Tran, Phuong Lan, Frija, Guy and Clement, Olivier (2004) Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. European Radiology, 14 11: 2125-2133. doi:10.1007/s00330-004-2339-8


Author Fournier, Laure S.
Cuenod, Charles Andre
de Bazelaire, Cedric de
Siauve, Nathalie
Rosty, Christophe
Tran, Phuong Lan
Frija, Guy
Clement, Olivier
Title Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent
Journal name European Radiology   Check publisher's open access policy
ISSN 0938-7994
1432-1084
Publication date 2004-11
Sub-type Article (original research)
DOI 10.1007/s00330-004-2339-8
Volume 14
Issue 11
Start page 2125
End page 2133
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Macromolecular contrast-enhanced functional CT was performed to characterize early perfusion changes in hepatocellular carcinoma (HCC). Fourteen rats with chemically induced primary liver tumors ranging pathologically from hyperplasia to HCC and 15 control rats were investigated. Two dynamic CT scans using an experimental macromolecular contrast agent were performed on a single slice 11 and 18 weeks after tumor induction followed by pathological examination. A deconvolution mathematical model was applied, yielding the hepatic perfusion index (HPI), mean transit time (MTT), liver distribution volume (LDV) and arterial, portal and total blood flows (FA, FP, FT). Analysis was performed on one slice per rat, containing overall two hyperplasia, six dysplasia and 15 HCC. On the first scans, HCC at an early pathological stage had a low FP (-30%, P=0.002) but a normal arterial-portal balance. On the scan contemporary to pathology, HCC perfusion parameters showed an inversion of the arterial-portal balance (HPI +212%, P<0.0001), with a high FA (+56%, P=0.002) and low FP P<0.0001). Sensitivity and specificity of detection of HCC by perfusion CT were high (87 and 80%) on late scans; but also on the earlier scans (86 and 65%), even though only one (7%) was visible to the eye. Perfusion-CT allowed early detection of HCC. This technique could contribute in the detection and characterization of liver lesions in clinical studies.
Keyword Angiogenesis
Perfusion imaging
Hepatocellular carcinoma
Computed tomography
Animal imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 14:20:24 EST