KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome

Azoulay, Sandy, Lae, Marick, Freneaux, Paul, Merle, Solange, Al Ghuzlan, Abir, Chnecker, Caroline, Rosty, Christophe, Klijanienko, Jerzy, Sigal-Zafrani, Brigitte, Salmon, Rémy, Fourquet, Alain, Sastre-Garau, Xavier and Vincent-Salomon, Anne (2005) KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Modern Pathology, 18 12: 1623-1631. doi:10.1038/modpathol.3800483

Author Azoulay, Sandy
Lae, Marick
Freneaux, Paul
Merle, Solange
Al Ghuzlan, Abir
Chnecker, Caroline
Rosty, Christophe
Klijanienko, Jerzy
Sigal-Zafrani, Brigitte
Salmon, Rémy
Fourquet, Alain
Sastre-Garau, Xavier
Vincent-Salomon, Anne
Title KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome
Journal name Modern Pathology   Check publisher's open access policy
ISSN 0893-3952
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1038/modpathol.3800483
Volume 18
Issue 12
Start page 1623
End page 1631
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Recent biological studies have classified breast carcinomas into HER2-overexpressing, estrogen receptor-positive/luminal, basal- and normal-like groups. According to this new biological classification, the objectives of our study were to assess the clinical, morphologic and immunophenotypic characteristics of adenoid cystic carcinoma of the breast in order to classify this subtype of breast carcinoma. A total of 18 cases of adenoid cystic carcinoma were identified from the Institut Curie files. Clinical information was available for 16 patients with a median follow-up of 6.5 years. Morphologically, all tumors were graded according to the system defined by Kleer and Oberman (histologic and nuclear grade). Immunophenotype was assessed with anti-ER, PR, HER-2, KIT, basal (CK5/6) and luminal cytokeratins (CK8/18) and p63 antibodies. One out of 18 tumors was nuclear grade 1 (16%), nine were nuclear grade 2 (50%) and eight were nuclear grade 3 (44%). All cases were estrogen receptor, progesterone receptor and HER-2 negative. Epithelial cells were strongly positive around glandular lumina with one or both cytokeratins, identifying the coexistence of CK5/6+ cells, CK5/6 and CK8/18+ cells, CK8/18+ cells and p63+ cells. All cases (100%) were also KIT positive. In all, 15 patients were treated by surgery. Nine of them received adjuvant radiotherapy. Follow-up was available for 16 patients. In all, 14 patients were alive. Two of them, initially treated by surgery only, presented a local recurrence. Two patients died (one of them treated by radiation therapy only died from her disease). Our study shows that adenoid cystic carcinoma of the breast is a special, estrogen receptor, progesterone receptor, HER-2 negative and highly KIT-positive, basal-like breast carcinoma, associated with an excellent prognosis. This highly specific immunophenotype could be useful to differentiate adenoid cystic carcinoma of the breast from other subtypes of breast carcinoma such as cribriform carcinoma.
Keyword adenoid cystic carcinoma
basal carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Wed, 09 Mar 2011, 14:19:23 EST