The FA connectome: A quantitative strategy for studying neurological disease processes

Rose, Stephen, Pannek, Kerstin, Salvado, Oliver, Raniga, Parnesh, Baumann, Fusun and Henderson, Robert (2010). The FA connectome: A quantitative strategy for studying neurological disease processes. In: 18th International Society of Magnetic Resonance in Medicine (ISMRM) Scientific Meeting, Stockholm, Sweden, (). 1-7 May 2010.

Author Rose, Stephen
Pannek, Kerstin
Salvado, Oliver
Raniga, Parnesh
Baumann, Fusun
Henderson, Robert
Title of paper The FA connectome: A quantitative strategy for studying neurological disease processes
Conference name 18th International Society of Magnetic Resonance in Medicine (ISMRM) Scientific Meeting
Conference location Stockholm, Sweden
Conference dates 1-7 May 2010
Publication Year 2010
Sub-type Fully published paper
Language eng
Abstract/Summary Structural connectivity indices derived using diffusion based HARDI or q-ball imaging in conjunction with functional parcellation of the cortex from high resolution MRI, has provided insight into the anatomical conformation of many of the important neural networks in the living brain. We are developing the concept of the FA connectome, i.e. combining a measure of fractional anisotropy, a quantitative diffusivity metric that reflects the integrity of WM pathways, with the connectivity matrix. When applied to study Amyotrophic Lateral Sclerosis, this technique shows identifies a number of key corticomotor pathways with reduced mean FA compared to control participants.
Subjects 11 Medical and Health Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 09 Mar 2011, 11:31:47 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging