Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat

Powers, Scott K., Demirel, Haydar A., Vincent, Heather K., Coombes, Jeff S., Naito, Hisashi, Hamilton, Karyn L., Shanely, R. Andrew and Jessup, James (1998) Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. American Journal of Physiology, 275 5: R1468-R1477.

Author Powers, Scott K.
Demirel, Haydar A.
Vincent, Heather K.
Coombes, Jeff S.
Naito, Hisashi
Hamilton, Karyn L.
Shanely, R. Andrew
Jessup, James
Title Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat
Journal name American Journal of Physiology   Check publisher's open access policy
ISSN 0363-6119
Publication date 1998-11
Sub-type Article (original research)
Volume 275
Issue 5
Start page R1468
End page R1477
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
Experimental studies examining the effects of regular exercise on cardiac responses to ischemia and reperfusion (I/R) are limited. Therefore, these experiments examined the effects of endurance exercise training on myocardial biochemical and physiological responses during in vivo I/R. Female Sprague-Dawley rats (4 mo old) were randomly assigned to either a sedentary control group or to an exercise training group. After a 10-wk endurance exercise training program, animals were anesthetized and mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was achieved by a ligature around the left coronary artery; occlusion was maintained for 20 min, followed by a 10-min period of reperfusion. Compared with untrained, exercise-trained animals maintained higher (P < 0.05) peak systolic blood pressure throughout I/R. Training resulted in a significant (P < 0.05) increase in ventricular nonprotein thiols, heat shock protein (HSP) 72, and the activities of superoxide dismutase (SOD), phosphofructokinase (PFK), and lactate dehydrogenase. Furthermore, compared with untrained controls, left ventricles from trained animals exhibited lower levels (P < 0.05) of lipid peroxidation after I/R. These data demonstrate that endurance exercise training improves myocardial contractile performance and reduces lipid peroxidation during I/R in the rat in vivo. It appears likely that the improvement in the myocardial responses to I/R was related to training-induced increases in nonprotein thiols, HSP72, and the activities of SOD and PFK in the myocardium.
Keyword Endurance exercise
Free radicals
Cardiac hypertrophy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
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Created: Wed, 09 Mar 2011, 08:54:19 EST