Exercise-induced alterations in skeletal muscle myosin heavy chain phenotype: dose-response relationship

Demirel, Haydar A., Powers, Scott K., Naito, Hisashi, Hughes, Michael and Coombes, Jeff S. (1999) Exercise-induced alterations in skeletal muscle myosin heavy chain phenotype: dose-response relationship. European Journal of Applied Physiology, 86 3: 1002-1008.

Author Demirel, Haydar A.
Powers, Scott K.
Naito, Hisashi
Hughes, Michael
Coombes, Jeff S.
Title Exercise-induced alterations in skeletal muscle myosin heavy chain phenotype: dose-response relationship
Journal name European Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 1999-03
Sub-type Article (original research)
Volume 86
Issue 3
Start page 1002
End page 1008
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
This study investigated the effects of exercise training duration on the myosin heavy chain (MHC) isoform distribution in rat locomotor muscles. Female Sprague-Dawley rats (120 days old) were assigned to either a sedentary control group or to one of three endurance exercise training groups. Trained animals ran on a treadmill at ∼75% maximal O2 uptake for 10 wk (4–5 days/wk) at one of three different exercise durations (30, 60, or 90 min/day). Training resulted in increases (P < 0.05) in citrate synthase activity in the soleus and extensor digitorum longus in both the 60 and 90 min/day duration groups and in the plantaris (Pla) in all three exercise groups. All durations of training resulted in a reduction (P < 0.05) in the percentage of MHCIIb and an increase (P < 0.05) in the percentage of MHCIIa in the Pla. The magnitude of change in the percentage of MHCIIb in the Pla increased as a function of the training duration. In the extensor digitorum longus, 90 min of daily exercise promoted a decrease (P < 0.05) in percentage of MHCIIb and increases (P < 0.05) in the percentages of MHCI, MHCIIa, and MHCIId/x. Finally, training durations ≥60 min resulted in an increase (P < 0.05) in the percentage of MHCI and a concomitant decrease (P < 0.05) in the percentage of MHCIIa in the soleus. These results demonstrate that increasing the training duration elevates the magnitude of the fast-to-slow shift in MHC phenotype in rat hindlimb muscles.
Keyword Endurance exercise
Muscle plasticity
Fiber type
Oxidative capacity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 09 Mar 2011, 08:52:34 EST