Effects of vitamin E and dihydrolipoic acid on diaphragmatic contractile properties

Coombes, J. S., Ward, K. H., Shanely, R. A., Powers, S. K. and Demirel, H. A. (1998). Effects of vitamin E and dihydrolipoic acid on diaphragmatic contractile properties. In: -, -, (A418-A418). -.

Author Coombes, J. S.
Ward, K. H.
Shanely, R. A.
Powers, S. K.
Demirel, H. A.
Title of paper Effects of vitamin E and dihydrolipoic acid on diaphragmatic contractile properties
Conference name -
Conference location -
Conference dates -
Journal name FASEB Journal   Check publisher's open access policy
Place of Publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Publication Year 1998
Sub-type Published abstract
Open Access Status
ISSN 0892-6638
Volume 12
Issue 4
Start page A418
End page A418
Total pages 1
Language eng
Abstract/Summary Previous work in our laboratory has demonstrated that dietary supplementation with both vitamin E (VE) and alpha-lipoic acid (converted to dihydrolipoic acid (DHLA) in the cell) results in a right shift of the force-frequency (f/f) curve of the tibialis anterior muscle in rats. Therefore, these experiments were designed to determine the combined influence of VE and DHLA on rat skeletal muscle contractile properties. We tested the hypothesis that direct exposure of skeletal muscle to these antioxidants results in a right shift of the f/f curve. Diaphragmatic contractile properties were assessed in vitro at 37 degrees C before and after a 30 min incubation period with VE (250μM) and DHLA (500μM) added to the bath. Contractile measurements included maximal specific tension (Po), maximal twitch tension (Pt), 1/2 time to peak tension (1/2 tpt), 1/2 relaxation time (1/2rt), rate of force production (dP/dt) and force-frequency (f/f) relationship. Exposure to VE and DHLA resulted in a significant reduction (P<0.05) in Pt and a right shift in the f/f curve. Specifically, there was a reduction (P<0.05) in specific force production at stimulation frequencies less than and equal to 40Hz. The antioxidant compounds did not alter Po, 1/2tpt, 1/2rt or dP/dt. These data support the hypothesis that high concentrations of the antioxidant compounds VE and DHLA result in decreased skeletal muscle force production at sub-maximal stimulation frequencies.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Human Movement and Nutrition Sciences Publications
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Created: Wed, 09 Mar 2011, 08:52:18 EST