A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome

Schrier, R. W. and Fassett, R. G. (1998) A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome. Kidney International, 53 5: 1111-1117.


Author Schrier, R. W.
Fassett, R. G.
Title A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome
Journal name Kidney International   Check publisher's open access policy
ISSN 0085-2538
Publication date 1998-05
Sub-type Article (original research)
DOI 10.1046/j.1523-1755.1998.00864.x
Volume 53
Issue 5
Start page 1111
End page 1117
Total pages 7
Language eng
Abstract A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome. Recent reviews have claimed that the majority of patients with the nephrotic syndrome have plasma volume expansion (that is, they are overfilled). Here we attempt to re-establish balance to the debate on body fluid volume status in nephrotic patients by: (a) discussing the conflicting literature on plasma volume measurements in the nephrotic syndrome; (b) providing alternate explanations for data purporting to support an overfill hypothesis in the nephrotic syndrome; (c) emphasizing secondary neurohumoral responses that support underfilling at least as frequently as overfilling; and (d) emphasizing the clinical importance of fluid assessment in the individual patient with the nephrotic syndrome particularly in relation to diuretic use.
Keyword Nephrotic syndrome
Sodium
Water
Edema
Acute Renal Failure
MINIMAL LESIONS
EDEMA FORMATION
BLOOD-VOLUME
HYPOPROTEINEMIA
ALDOSTERONE
EXCRETION
RECOVERY
TISSUE
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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