Effect of long-term cimetidine treatment on left ventricular function in haemodialysis patients with active hyperparathyroidism

Lai, K. N., Fassett, R. G. and Mathew, T. H. (1982) Effect of long-term cimetidine treatment on left ventricular function in haemodialysis patients with active hyperparathyroidism. British Journal of Clinical Pharmacology, 13 5: 693-697.


Author Lai, K. N.
Fassett, R. G.
Mathew, T. H.
Title Effect of long-term cimetidine treatment on left ventricular function in haemodialysis patients with active hyperparathyroidism
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
Publication date 1982
Sub-type Article (original research)
Volume 13
Issue 5
Start page 693
End page 697
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract The effect of long-term oral cimetidine on left ventricular function was evaluated in chronic haemodialysis patients with active hyperparathyroidism. Radionuclide ventriculography (7 patients) and echocardiography (5 patients) revealed a significant increase in ejection fraction and mean velocity of circumferential fibre shortening 6 months after treatment. The improved cardiac performance was associated with improvement of bone histology. C-terminal parathyroid hormone, serum calcium, and mean arterial pressure changed little after treatment. The improved cardiac performance is thought to be related to the suppression of uraemic hyperparathyroidism by cimetidine. The present study suggests that uraemic hyperparathyroidism may play an important role in uraemic cardiomyopathy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 09 Mar 2011, 08:44:42 EST