Histamine levels in stored human blood

Frewin, D. B., Jonsson, J. R., Head, R. J., Russell, W. J. and Beal, R. W. (1984) Histamine levels in stored human blood. Transfusion, 24 6: 502-504. doi:10.1046/j.1537-2995.1984.24685066810.x

Author Frewin, D. B.
Jonsson, J. R.
Head, R. J.
Russell, W. J.
Beal, R. W.
Title Histamine levels in stored human blood
Journal name Transfusion   Check publisher's open access policy
ISSN 0041-1132
Publication date 1984
Sub-type Article (original research)
DOI 10.1046/j.1537-2995.1984.24685066810.x
Volume 24
Issue 6
Start page 502
End page 504
Total pages 3
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell
Language eng
Abstract The histamine content in plasma samples obtained from a group of healthy blood donors, from blood stored in citrate-phosphate-dextrose supplemented with adenine (CPDA) packs for up to 28 days, and from the side arm of a transfusion line was measured by radio-enzymatic assay. Healthy donors had a mean plasma histamine content of 0.79 ng per ml. Blood stored in CPDA initially showed a similar histamine level (0.69 ng/ml on day 3 of storage), but there was a progressive rise with time, and at 28 days, the level was 20.5 ng per ml. The increase in histamine is best described by a positive exponential and may be explained by a process whereby the plasma histamine level increases the degree of histamine release from blood cells. The histamine levels in the blood infused into patients tended to be higher than those found in the stored units of the same age, if these packs were less than 7 days old. This may have been caused by the unit becoming warmer during transfusion. We speculate that the histamine levels in the older units of stored blood were high enough to cause or augment transfusion reactions and that the storage age of blood may have a bearing on the incidence of transfusion reactions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 09 Mar 2011, 08:37:06 EST