Epstein-barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells

Ishii, H. H. and Gobe, G. C. (1993) Epstein-barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells. Biochemical and Biophysical Research Communications, 192 3: 1415-1423. doi:10.1006/bbrc.1993.1574


Author Ishii, H. H.
Gobe, G. C.
Title Epstein-barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 1993-05
Sub-type Article (original research)
DOI 10.1006/bbrc.1993.1574
Volume 192
Issue 3
Start page 1415
End page 1423
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract Several papers have recorded that Epstein-Barr virus (EBV) infection can protect B-cells from apoptosis. In the present paper, we record an increase in apoptosis in an EB V-infected human Burkitt's lymphoma cell line (AW-Ramos), compared with its virus free counterpart (Ramos). The viral-infected cells died more rapidly by apoptosis during normal growth in culture: at 72h, Ramos cells had 8% apoptosis and AW-Ramos had 27% apoptosis. The EBV-infected cells were particularly sensitive to treatment with phorbol-12,13-dibutyrate (PDBu, 0.05·g/ml): at 72h, Ramos cells had 12% apoptosis and AW-Ramos had 42% apoptosis. DNA gel electrophoresis supported the morphological findings. Our results serve as a caveat against generalizations that may be made about prevention of apoptosis by EBV infection. Copyright © 1993 Academic Press. All rights reserved.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 09 Mar 2011, 08:33:33 EST