Effects of indomethacin on renal concentrating capacity in lithium-treated rats

Gobe, G. C. and Axelsen, R. A. (1983) Effects of indomethacin on renal concentrating capacity in lithium-treated rats. Research Communications in Chemical Pathology and Pharmacology, 39 1: 11-28.

Author Gobe, G. C.
Axelsen, R. A.
Title Effects of indomethacin on renal concentrating capacity in lithium-treated rats
Journal name Research Communications in Chemical Pathology and Pharmacology   Check publisher's open access policy
ISSN 0034-5164
Publication date 1983
Sub-type Article (original research)
Volume 39
Issue 1
Start page 11
End page 28
Total pages 18
Place of publication Westbury, United States
Publisher PJD Publications
Language eng
Formatted abstract
An investigation was carried out to determine whether or not the administration of indomethacin to Li-treated rats would raise P(Li)2, and whether or not there would be any change in the type or severity of Li-induced renal functional abnormalities. It was found that indomethacin increased P(Li), apparently by decreasing C(Li). U(max), already reduced by Li, was further impaired by the additional administration of indomethacin. The Li-induced impairment of T(c)H2O was not worsened by added indomethacin, but a wide variance of the data might have masked any effect. Significant inverse correlations were found between U(max) and P(Li) and between maximum T(c)H2O and P(Li), suggesting that the indomethacin-induced impairment in renal concentrating capacity is attributable to the increased P(Li).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 09 Mar 2011, 08:31:57 EST