Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination

Väkeväinen, Merja, Soininen, Anu, Lucero, Marilla, Nohynek, Hanna, Auranen, Kari, Mäkelä, P. Helena, Williams, Gail, Käyhty, Helena and ARIVAC Consortium (2010) Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination. Journal of Pediatrics, 157 5: 778-783.ei. doi:10.1016/j.jpeds.2010.04.071


Author Väkeväinen, Merja
Soininen, Anu
Lucero, Marilla
Nohynek, Hanna
Auranen, Kari
Mäkelä, P. Helena
Williams, Gail
Käyhty, Helena
ARIVAC Consortium
Title Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
1097-6833
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2010.04.071
Volume 157
Issue 5
Start page 778
End page 783.ei
Total pages 6
Place of publication Philadelphia, PA, U.S.A.
Publisher Mosby
Collection year 2011
Language eng
Formatted abstract
Objective: To determine whether pneumococcal carriage at the time of 11-valent pneumococcal conjugate vaccine (PCV-11) administration interferes with immune response in infants.
Study design: A total of 1111 Filipino infants recruited into an immunogenicity and carriage study, nested in an efficacy trial, received PCV-11 or saline solution placebo at 6, 10, and 14 weeks of age. Antibody concentrations to the most frequently carried vaccine serotypes 6B, 19F, and 23F were measured by enzyme immunoassay from sera obtained at 18 weeks and 9 months of age. Serotype-specific antibody concentration was compared between groups of children among PCV-11 recipients stratified according to their carriage status at 6 weeks of age.
Results: Antibody concentrations to 6B, 19F, and 23F were significantly lower at 18 weeks and 9 months of age among children who were carriers of the specific serotype at 6 weeks of age than among non-carriers of the serotype. The hyporesponsiveness was specific to the carried serotype. The specific antibody concentrations induced by PCV-11 among carriers did not differ significantly from those in placebo recipients, whereas the differences were highly significant among noncarriers.
Conclusions: Pneumococcal carriage, prevalent in Filipino infants, interferes with serotype-specific immune response to primary series of PCV and has potential implications for immunization programs.
© 2010 Mosby Inc. All rights reserved.
Keyword Geometric mean concentration
Intent-to-treat
Invasive pneumococcal disease
Pneumococcal conjugate vaccine
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Australian Centre for International & Tropical Health
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Created: Tue, 08 Mar 2011, 15:54:45 EST by Geraldine Fitzgerald on behalf of Australian Centre for International and Tropical Health and Nutrition