Vectoring of avian influenza antigens using a recombinant avian herpes virus vector

Hartawan, Risza, Meers, Joanne, Mahony, Tim and Robinson, Karl (2010). Vectoring of avian influenza antigens using a recombinant avian herpes virus vector. In: Global Biosecurity 2010: Safeguarding Agriculture and the Environment. Conference Handbook. Global Biosecurity 2010, Brisbane, QLD, Australia, (143-143). 28 February-3 March 2010.

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Author Hartawan, Risza
Meers, Joanne
Mahony, Tim
Robinson, Karl
Title of paper Vectoring of avian influenza antigens using a recombinant avian herpes virus vector
Conference name Global Biosecurity 2010
Conference location Brisbane, QLD, Australia
Conference dates 28 February-3 March 2010
Proceedings title Global Biosecurity 2010: Safeguarding Agriculture and the Environment. Conference Handbook
Publication Year 2010
Sub-type Poster
Start page 143
End page 143
Total pages 1
Language eng
Formatted Abstract/Summary
The emergence of highly pathogenic avian influenza (HPAI) virus subtype H5N1 in Asia, Africa and Europe has resulted in massive economic repercussions in affected countries, and poses a continuing serious zoonotic threat. This panzootic is caused by influenza A virus (antisense segmented RNA) from the Orthomyxoviridae family, which is characterised by variant genotypes and high mutation rates. Vaccination has been implemented in several countries as part of comprehensive programs to control the disease in both poultry and human populations. However, current bird vaccination strategies generate unsatisfactory outcomes, due largely to the lack of an ideal vaccine against the disease. Numerous studies that employ genetic modification have been undertaken to produce an improved vaccine. The objective of this study is to explore the capacity of the naturally non-pathogenic virus Herpesvirus of Turkey (HVT) as a vector to express the main immunogens of HPAI H5N1 virus, which are haemagglutinin (H5) and neuraminidase (N1). Segments 4 (H5) and 6 (N1) of the virus genome that encode these proteins were analysed from a duck-derived field isolate of H5N1, and this information was used to design and construct synthetic H5 and N1 genes. These genes are being introduced into a HVT infectious clone using a bacterial recombination system. The expression level of the proteins of interest in the recombinant HVT is being evaluated by in vitro characterization methods. The vectoring system for H5N1 virus using HVT as a backbone will contribute to knowledge on the control of such highly genetically variable viruses.
Subjects 0601 Biochemistry and Cell Biology
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Presented as Poster no. 10.

 
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Created: Mon, 07 Mar 2011, 15:49:05 EST by Assoc Prof Joanne Meers on behalf of School of Veterinary Science