A blowfly strike vaccine requires an understanding of host-pathogen interactions

Elkington, Rebecca A. and Mahony, Timothy J. (2007) A blowfly strike vaccine requires an understanding of host-pathogen interactions. Vaccine, 25 28: 5133-5145.


Author Elkington, Rebecca A.
Mahony, Timothy J.
Title A blowfly strike vaccine requires an understanding of host-pathogen interactions
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
1873-2518
Publication date 2007-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.vaccine.2007.04.074
Volume 25
Issue 28
Start page 5133
End page 5145
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract The phase-out of Mulesing by 2010 means the Australian wool industry requires immediate and viable alternatives for the control and prevention of blowfly strike, an economically important parasitic disease of sheep. In this review we have analysed previous research aimed toward the development of a vaccine against blowfly strike and the reasons why the approaches taken were unsuccessful at the time. Close scrutiny has provided new insight into this host–parasite interaction and identified new opportunities for the development of a vaccine. Here we propose that addressing immunosuppression together with the induction of cellular immunity is likely to result in an anti-blowfly strike vaccine, as opposed to the use of “standard” approaches aimed at inducing humoral immunity.
Keyword Lucilia Cuprina
Vaccine
Immune Response
Immunosuppression
Lucilia-cuprina Larvae
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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