Comparison of the efficacy of a subunit and a live streptomycin-dependent porcine pleuropneumonia vaccine

Tumamao, J. Q., Bowles, R. E., Van den Bosch, H., Klaasen, H. L. B. M., Fenwick, B. W., Storie, G. J. and Blackall, P. J. (2004) Comparison of the efficacy of a subunit and a live streptomycin-dependent porcine pleuropneumonia vaccine. Australian Veterinary Journal, 82 6: 370-374. doi:10.1111/j.1751-0813.2004.tb11108.x

Author Tumamao, J. Q.
Bowles, R. E.
Van den Bosch, H.
Klaasen, H. L. B. M.
Fenwick, B. W.
Storie, G. J.
Blackall, P. J.
Title Comparison of the efficacy of a subunit and a live streptomycin-dependent porcine pleuropneumonia vaccine
Journal name Australian Veterinary Journal   Check publisher's open access policy
ISSN 0005-0423
Publication date 2004-06
Sub-type Article (original research)
DOI 10.1111/j.1751-0813.2004.tb11108.x
Volume 82
Issue 6
Start page 370
End page 374
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Objective: To evaluate the efficacy of two new-generation porcine pleuropneumonia vaccines when challenged with Australian isolates of Actinobacillus pleuropneumoniae of serovars 1 and 15.

Design: The Porcilis APP vaccine and an experimental streptomycin-dependent strain of A pleuropneumoniae were evaluated in a standardised pen trial. Each vaccine/challenge group consisted of 10 pigs.

Results: With the serovar 1 challenge, the Porcilis APP vaccine and the live vaccine, compared with the control group, gave significant protection in terms of clinical signs, lung lesions, re-isolation scores and average daily gain (ADG) postchallenge. Only the Porcilis APP vaccine provided significant protection against mortality. In the serovar 15 challenged pigs, the only significant difference detected was that the Porcilis APP vaccinated pigs had a better postchallenge ADG than the controls. None of the Porcilis APP vaccinated pigs showed signs of depression postvaccination and none were euthanased after challenge with either serovar 1 or 15. The pigs vaccinated with the live vaccine showed obvious depression after each vaccination and a total of 3 pigs were euthanased after challenge (one with serovar 1 and two with serovar 15).

Conclusions: Both of the vaccines provided significant protection against a severe challenge with serovar 1 A pleuropneumoniae. Neither vaccine was effective against a serovar 15 A pleuropneumoniae challenge. There was evidence that the Porcilis APP vaccine did provide some protection against the serovar 15 challenge because the ADG, after challenge of pigs given this vaccine, was greater than the control pigs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 07 Mar 2011, 14:44:43 EST